901 TSLP and SDF-1a/CXCR4 axis in skin fibrosis
نویسندگان
چکیده
منابع مشابه
SDF-1 axis and myocardial repair.
THE ABILITY OF THE HEART to sustain hemodynamic demands is greatly challenged when cell loss or disruption of myocardial homeostasis occurs. Cell therapy using stem or progenitor cells is a promising option to restore the lost myocardium and normalize ventricular function. Initial clinical trials have documented the feasibility and safety of this therapeutic approach with an indication of the p...
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BACKGROUND Tetramethylpyrazine (TMP) is one of the active ingredients extracted from the Chinese herb Chuanxiong, which has been used to treat cerebrovascular and cardiovascular diseases, pulmonary diseases and cancer. However, the molecular mechanisms underlying the actions of TMP have not been fully elucidated. In a previous study we showed that TMP-mediated glioma suppression and neural prot...
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Inflammatory angiogenesis and vascular remodeling play key roles in the chronic inflammatory skin disease psoriasis, but little is known about the molecular mediators of vascular activation. Based on the reported elevated mRNA levels of the angiogenic chemokine stromal cell-derived factor-1 (SDF-1) and its receptor CXCR4 in psoriasis, we investigated the relevance of the SDF-1/CXCR4 axis in two...
متن کاملImportance of the SDF-1:CXCR4 axis in myocardial repair.
Since the original descriptions of the role of stromal cell-derived factor (SDF)-1 in recruiting bone marrow derived stem cells to the sites of vascular1 and myocardial injury,2 there has been increasing evidence of the broader importance of the SDF-1:CXCR4 axis in regulating myocardial repair following ischemic injury.2–6 In this issue of Circulation Research, Tang et al investigate the role o...
متن کاملStem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis
The skeletal muscle regeneration occurs due to the presence of tissue specific stem cells - satellite cells. These cells, localized between sarcolemma and basal lamina, are bound to muscle fibers and remain quiescent until their activation upon muscle injury. Due to pathological conditions, such as extensive injury or dystrophy, skeletal muscle regeneration is diminished. Among the therapies ai...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2017
ISSN: 0022-202X
DOI: 10.1016/j.jid.2017.02.928